John L Wallace Selected Research

Colitis

5/2021	Increased Mucosal Thrombin is Associated with Crohn's Disease and Causes Inflammatory Damage through Protease-activated Receptors Activation.
1/2020	Giardia spp. promote the production of antimicrobial peptides and attenuate disease severity induced by attaching and effacing enteropathogens via the induction of the NLRP3 inflammasome.
1/2017	Giardia co-infection promotes the secretion of antimicrobial peptides beta-defensin 2 and trefoil factor 3 and attenuates attaching and effacing bacteria-induced intestinal disease.
5/2015	Hydrogen sulfide protects from colitis and restores intestinal microbiota biofilm and mucus production.
4/2015	Proresolution effects of hydrogen sulfide during colitis are mediated through hypoxia-inducible factor-1α.
9/2014	Impaired hydrogen sulfide synthesis and IL-10 signaling underlie hyperhomocysteinemia-associated exacerbation of colitis.
1/2013	Enhanced synthesis and diminished degradation of hydrogen sulfide in experimental colitis: a site-specific, pro-resolution mechanism.
6/2010	A pro-resolution mediator, prostaglandin D(2), is specifically up-regulated in individuals in long-term remission from ulcerative colitis.
8/2009	Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats.
10/2006	5-Amino-2-hydroxybenzoic acid 4-(5-thioxo-5H-[1,2]dithiol-3yl)-phenyl ester (ATB-429), a hydrogen sulfide-releasing derivative of mesalamine, exerts antinociceptive effects in a model of postinflammatory hypersensitivity.

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John L Wallace Research Topics

Disease

54	Inflammation (Inflammations) 08/2023 - 08/2002
17	Ulcer 04/2024 - 10/2002
14	Colitis 05/2021 - 09/2003
12	Stomach Ulcer (Gastric Ulcer) 04/2024 - 10/2002
8	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 05/2021 - 11/2002
8	Hemorrhage 11/2020 - 11/2008
8	Neoplasms (Cancer) 01/2018 - 01/2005
7	Edema (Dropsy) 01/2014 - 08/2002
6	Pain (Aches) 10/2021 - 01/2006
5	Arthritis (Polyarthritis) 01/2018 - 04/2005
4	Hyperalgesia 11/2020 - 07/2006
4	Dysbiosis 06/2015 - 10/2011
3	Osteoarthritis 08/2023 - 03/2009
3	Weight Loss (Weight Reduction) 01/2020 - 11/2004
3	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 01/2019 - 09/2010
3	Hypertension (High Blood Pressure) 01/2018 - 04/2006
3	Intestinal Diseases (Diseases, Intestinal) 01/2017 - 09/2003
3	Colonic Neoplasms (Colon Cancer) 09/2014 - 11/2005
3	Hyperplasia 01/2014 - 02/2002
3	Ulcerative Colitis 01/2012 - 11/2002
2	Hypoxia (Hypoxemia) 08/2023 - 04/2015
2	Wounds and Injuries (Trauma) 08/2023 - 12/2007
2	Crohn Disease (Crohn's Disease) 05/2021 - 11/2002
2	Coinfection 01/2020 - 01/2017
2	Nausea 01/2020 - 01/2008
2	Liver Diseases (Liver Disease) 01/2019 - 02/2002
2	Pathologic Processes 01/2018 - 05/2015
2	Hyperemia 01/2015 - 01/2008
2	Spinal Cord Injuries (Spinal Cord Injury) 12/2014 - 11/2013
2	Aberrant Crypt Foci 09/2014 - 11/2005
2	Colorectal Neoplasms (Colorectal Cancer) 09/2014 - 11/2005
2	Infections 04/2009 - 12/2006
2	Cardiovascular Diseases (Cardiovascular Disease) 12/2007 - 12/2005

Drug/Important Bio-Agent (IBA)

34	Hydrogen Sulfide (Sulfide, Hydrogen)IBA 08/2023 - 01/2006
22	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 04/2024 - 04/2004
12	Naproxen (Naprosyn)FDA LinkGeneric 10/2021 - 03/2010
12	2-(6-methoxy-napthalen-2-yl)-propionic acid 4-thiocarbamoyl-phenyl esterIBA 10/2021 - 03/2010
11	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2019 - 02/2002
10	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 10/2021 - 10/2002
9	EnzymesIBA 08/2023 - 02/2006
7	CytokinesIBA 04/2024 - 10/2007
7	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 04/2024 - 05/2002
7	Acetic Acid (Vinegar)FDA LinkGeneric 04/2024 - 10/2002
7	Peptide Hydrolases (Proteases)FDA Link 05/2021 - 11/2002
7	ProstaglandinsIBA 06/2010 - 01/2003
6	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 12/2015 - 10/2002
6	Celecoxib (Celebrex)FDA Link 01/2012 - 03/2002
5	AcidsIBA 05/2021 - 12/2005
5	Proteinase-Activated ReceptorsIBA 05/2021 - 08/2002
5	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 12/2016 - 01/2003
5	CarrageenanIBA 11/2013 - 08/2002
4	GasotransmittersIBA 05/2015 - 08/2009
4	HaptensIBA 05/2015 - 11/2004
4	sodium bisulfide (NaHS)IBA 01/2015 - 01/2006
4	Peptides (Polypeptides)IBA 01/2012 - 08/2002
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 06/2006 - 10/2002
3	HydrogenIBA 04/2024 - 02/2010
3	LyasesIBA 08/2023 - 04/2015
3	CystathionineIBA 08/2023 - 04/2015
3	Messenger RNA (mRNA)IBA 08/2023 - 10/2006
3	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 08/2023 - 12/2006
3	Thrombin FDA Link 05/2021 - 08/2002
3	AntioxidantsIBA 01/2019 - 10/2004
3	diallyl disulfide (diallyl disulphide)IBA 05/2015 - 02/2015
3	Sulfonic AcidsIBA 04/2015 - 11/2004
3	Cyclooxygenase InhibitorsIBA 12/2014 - 10/2002
3	LipoxinsIBA 01/2012 - 07/2003
3	Phenobarbital (Luminal)FDA Link 10/2008 - 11/2002
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 08/2008 - 10/2002
3	Adenosine Triphosphate (ATP)IBA 12/2007 - 10/2006
2	Proteins (Proteins, Gene)FDA Link 04/2024 - 03/2008
2	Heme Oxygenase-1IBA 04/2024 - 08/2023
2	Cyclooxygenase 1IBA 08/2023 - 03/2010
2	Indomethacin (Indometacin)FDA LinkGeneric 08/2023 - 09/2004
2	Interleukin-1beta (Interleukin 1 beta)IBA 08/2023 - 04/2005
2	Ketoprofen (Orudis)FDA LinkGeneric 11/2020 - 01/2018
2	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 01/2015 - 10/2013
2	Cysteine (L-Cysteine)FDA Link 01/2015 - 12/2007
2	AzoxymethaneIBA 09/2014 - 11/2005
2	Drinking WaterIBA 01/2014 - 01/2008
2	EstersIBA 11/2013 - 10/2006
2	Proton Pump InhibitorsIBA 10/2011 - 12/2005
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2009 - 11/2004
2	GlucocorticoidsIBA 03/2008 - 07/2003
2	Capsaicin (Zostrix)FDA Link 01/2008 - 09/2003
2	nitroaspirinIBA 12/2007 - 01/2004
2	Diclofenac (SR 38)FDA LinkGeneric 01/2007 - 10/2006
2	EndostatinsIBA 06/2006 - 10/2002
2	Irritants (Vesicants)IBA 01/2006 - 11/2004
2	lipoxin A4IBA 11/2004 - 07/2003
2	Acetaminophen (Paracetamol)FDA LinkGeneric 09/2004 - 02/2002
2	(3- 4- (2- fluoromethyl- (1,1'- biphenyl)- 4- acetyloxy)- 3- methoxyphenyl)- 2- propenoic acid 4-nitrooxy butyl esterIBA 05/2004 - 03/2002
1	Oxidoreductases (Dehydrogenase)IBA 04/2024
1	Nucleic AcidsIBA 04/2024
1	DesmosterolIBA 04/2024
1	TransferasesIBA 08/2023
1	Xanthine OxidaseIBA 08/2023

Therapy/Procedure

10	Therapeutics 12/2016 - 11/2005
7	Chemoprevention 01/2018 - 10/2013
3	Oral Administration 02/2015 - 09/2004